The Luxembourg Institute of Health maintains a database of proteins involved in this process in humans. Through its interaction with RAB7A, Rubicon is one of the few known negative regulators of this process. Fluorescent dots of LC3 are used to confirm the presence of this process. VPS34 phosphorylates inositol phospholipid at the start of this process as part of the Beclin-1 complex after being activated by ULK kinases, which are downregulated by (*) mTOR. In yeast, this process is regulated by the ATG genes. The “macro” form of this process results in the formation of a double-membrane vesicle around cytoplasmic components, which fuses with a lysosome for degradation. Yoshinori Ohsumi won the 2016 Nobel Prize in Physiology for his work on this process. For 10 points, name this process where a cell recycles its own material. ■END■
ANSWER: autophagy [or autophagocytosis; accept macroautophagy; prompt on lysosome formation by asking, “what other process does that result in?”] (The organelle is the phagosome.)
<Science - Biology>
= Average correct buzz position