Question

The D-site loses this structure due to distortion by Glu and Asp side chains in the mechanism of lysozyme. The Zimmerman-Traxler model predicts the aldol reaction's stereochemistry by assuming the transition state has this specific structure and analyzing the steric interactions. Transition states with this structure are thermodynamically favored for [3+3]-rearrangements like the Claisen and (*) Cope rearrangements. (-5[1])The Newman projection for this conformation is fully staggered, while it is fully gauche for a different conformation that experiences ■END■ (10[1])

ANSWER: chair conformation [prompt on ring or cyclic structure; prompt on cyclohexane]
<JZ, Chemistry>
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Shaun IyerInnovation Academy AGeorgia Tech C56-5
Rohan DalalGeorgia Tech AMississippi State7710
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