Question
Two answers required. Worldwide shortages starting in 2023 led to rationing of semaglutide, a GLP-1 receptor agonist that regulates the level of these two molecules. For 10 points each:
[10m] Name these two molecules. One of these molecules activates the GLUT4 transporter after its C-peptide is cleaved and the other is produced by alpha cells in the pancreas.
ANSWER: insulin AND glucagon
[10e] Semaglutide, or Ozempic, promotes insulin secretion and inhibits glucagon release to treat obesity and this other condition. This condition is characterized by insulin resistance, unlike its type 1 counterpart.
ANSWER: type 2 diabetes mellitus [or T2D; accept adult-onset diabetes; prompt on diabetes mellitus or DM]
[10h] Ozempic is an analog of GLP-1, which is one of the major members of this group of hormones along with gastric inhibitory peptide. These hormones augment insulin secretion to decrease blood glucose levels.
ANSWER: incretins
<Biology>
Summary
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