Question
Two answers required. Worldwide shortages starting in 2023 led to rationing of semaglutide, a GLP-1 receptor agonist that regulates the level of these two molecules. For 10 points each:
[10m] Name these two molecules. One of these molecules activates the GLUT4 transporter after its C-peptide is cleaved and the other is produced by alpha cells in the pancreas.
ANSWER: insulin AND glucagon
[10e] Semaglutide, or Ozempic, promotes insulin secretion and inhibits glucagon release to treat obesity and this other condition. This condition is characterized by insulin resistance, unlike its type 1 counterpart.
ANSWER: type 2 diabetes mellitus [or T2D; accept adult-onset diabetes; prompt on diabetes mellitus or DM]
[10h] Ozempic is an analog of GLP-1, which is one of the major members of this group of hormones along with gastric inhibitory peptide. These hormones augment insulin secretion to decrease blood glucose levels.
ANSWER: incretins
<Biology>
Summary
| 2024 ACF Winter at UC Berkeley | 2024-11-16 | Y | 2 | 25.00 | 100% | 100% | 50% |
| 2024 ACF Winter at Northwestern | 2024-11-16 | Y | 9 | 16.67 | 100% | 67% | 0% |
| 2024 ACF Winter at Online | 2024-11-16 | Y | 6 | 13.33 | 100% | 33% | 0% |
| 2024 ACF Winter at UBC | 2024-11-16 | Y | 2 | 15.00 | 100% | 50% | 0% |
| 2024 ACF Winter at Central Florida | 2024-11-16 | Y | 2 | 20.00 | 100% | 100% | 0% |
| 2024 ACF Winter at Oxford | 2024-11-16 | Y | 8 | 20.00 | 100% | 75% | 25% |
Data
| Berkeley B | Stanford A | 10 | 10 | 0 | 20 |
| Stanford L | Stanford M | 10 | 10 | 10 | 30 |
| Northwestern A | UChicago D | 10 | 10 | 0 | 20 |
| Notre Dame | UChicago A | 10 | 10 | 0 | 20 |
| Purdue A | UIUC C | 10 | 10 | 0 | 20 |
| Purdue C | UIUC D | 0 | 10 | 0 | 10 |
| UChicago C | Indiana A | 0 | 10 | 0 | 10 |
| UChicago B | UIUC A | 10 | 10 | 0 | 20 |
| UIUC B | Purdue D | 10 | 10 | 0 | 20 |
| WashU B | Purdue B | 10 | 10 | 0 | 20 |
| WashU D | SIUE A | 0 | 10 | 0 | 10 |
| Central Oklahoma | Texas D | 0 | 10 | 0 | 10 |
| Missouri | McGill E | 0 | 10 | 0 | 10 |
| NYU A | Oregon State | 0 | 10 | 0 | 10 |
| Texas A | Arkansas | 0 | 10 | 0 | 10 |
| Texas B | Vassar B | 10 | 10 | 0 | 20 |
| Vassar A | WUSTL A | 10 | 10 | 0 | 20 |
| Alberta | UW B | 10 | 10 | 0 | 20 |
| UW A | UBC A | 0 | 10 | 0 | 10 |
| UF B | Florida Tech B | 10 | 10 | 0 | 20 |
| UF A | UCF A | 10 | 10 | 0 | 20 |
| Bristol B | Birmingham | 0 | 10 | 0 | 10 |
| Cambridge A | LSE A | 10 | 10 | 0 | 20 |
| Cambridge D | Bristol A | 10 | 10 | 0 | 20 |
| Imperial A | LSE B | 10 | 10 | 10 | 30 |
| Oxford A | Durham B | 10 | 10 | 0 | 20 |
| Cambridge C | Oxford B | 10 | 10 | 10 | 30 |
| Southhampton B | Manchester | 10 | 10 | 0 | 20 |
| Vanderbilt | Warwick A | 0 | 10 | 0 | 10 |