insulin AND glucagon - 2024 ACF Winter at Central Florida

Question

Two answers required. Worldwide shortages starting in 2023 led to rationing of semaglutide, a GLP-1 receptor agonist that regulates the level of these two molecules. For 10 points each:

[10m] Name these two molecules. One of these molecules activates the GLUT4 transporter after its C-peptide is cleaved and the other is produced by alpha cells in the pancreas.

ANSWER: insulin AND glucagon

[10e] Semaglutide, or Ozempic, promotes insulin secretion and inhibits glucagon release to treat obesity and this other condition. This condition is characterized by insulin resistance, unlike its type 1 counterpart.

ANSWER: type 2 diabetes mellitus [or T2D; accept adult-onset diabetes; prompt on diabetes mellitus or DM]

[10h] Ozempic is an analog of GLP-1, which is one of the major members of this group of hormones along with gastric inhibitory peptide. These hormones augment insulin secretion to decrease blood glucose levels.

ANSWER: incretins

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Summary


2024 ACF Winter at UC Berkeley	2024-11-16	Y	2	25.00	100%	100%	50%
2024 ACF Winter at Clemson	2024-11-16	Y	4	15.00	100%	50%	0%
2024 ACF Winter at Northwestern	2024-11-16	Y	9	16.67	100%	67%	0%
2024 ACF Winter at Online	2024-11-16	Y	6	13.33	100%	33%	0%
2024 ACF Winter at UBC	2024-11-16	Y	2	15.00	100%	50%	0%
2024 ACF Winter at Central Florida	2024-11-16	Y	2	20.00	100%	100%	0%
2024 ACF Winter at Oxford	2024-11-16	Y	8	20.00	100%	75%	25%
2024 ACF Winter at Lehigh	2024-11-16	N	7	11.43	71%	14%	29%
2024 ACF Winter at Northwestern	2024-11-16	N	9	13.33	67%	56%	11%
2024 ACF Winter at Ohio State	2024-11-16	N	9	7.78	56%	0%	22%
2024 ACF Winter at Online	2024-11-16	N	7	10.00	57%	29%	14%
2024 ACF Winter at Central Florida	2024-11-16	N	4	12.50	100%	0%	25%
2024 ACF Winter at Oxford	2024-11-16	N	8	15.00	100%	38%	13%

Data


UF B	Florida Tech B	10	10	0	20
UF A	UCF A	10	10	0	20