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Overexpression of the Snail family of transcription factors suppresses the expression of this protein. For 10 points each:
[10h] Name this tumor suppressor that causes cancerous cells to adhere to the epithelium instead of metastasizing. It is broken down in the epithelial–mesenchymal (“meh-ZANK-uh-mull”) transition.
ANSWER: E-cadherin [or epithelial cadherin; accept Cadherin-1 or CDH1; prompt on cadherin]
[10m] Cancer cells that have stopped expressing E-cadherin can be treated with chimeric antigen receptors expressed by these cells. FOXP3 (“fox-P-three”) regulates the expression of the “regulatory” type of these cells.
ANSWER: T cells [or T lymphocytes; accept CD4 T cells; or CD8 T cells; or helper T cells; or cytotoxic T cells; or regulatory T cells; or cytotoxic T cells; or chimeric antigen receptor T cells; or CAR T cells; prompt on white blood cells; prompt on lymphocytes]
[10e] T cells and other immune cells can become cancerous in their own right in this disease. This disease is generally categorized into either the Hodgkin or non-Hodgkin subtypes.
ANSWER: lymphoma [or Hodgkin lymphoma or non-Hodgkin lymphoma]
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Columbia CJohn Jay0101020
Columbia AJohns Hopkins0101020
PennHaverford0101020
RowanNYU B001010
Columbia BVassar10101030