Question
Overexpression of the Snail family of transcription factors suppresses the expression of this protein. For 10 points each:
[10h] Name this tumor suppressor that causes cancerous cells to adhere to the epithelium instead of metastasizing. It is broken down in the epithelial–mesenchymal (“meh-ZANK-uh-mull”) transition.
ANSWER: E-cadherin [or epithelial cadherin; accept Cadherin-1 or CDH1; prompt on cadherin]
[10m] Cancer cells that have stopped expressing E-cadherin can be treated with chimeric antigen receptors expressed by these cells. FOXP3 (“fox-P-three”) regulates the expression of the “regulatory” type of these cells.
ANSWER: T cells [or T lymphocytes; accept CD4 T cells; or CD8 T cells; or helper T cells; or cytotoxic T cells; or regulatory T cells; or cytotoxic T cells; or chimeric antigen receptor T cells; or CAR T cells; prompt on white blood cells; prompt on lymphocytes]
[10e] T cells and other immune cells can become cancerous in their own right in this disease. This disease is generally categorized into either the Hodgkin or non-Hodgkin subtypes.
ANSWER: lymphoma [or Hodgkin lymphoma or non-Hodgkin lymphoma]
<Biology>
Summary
| 2024 ACF Regionals @ Berkeley | 01/27/2024 | Y | 3 | 13.33 | 100% | 33% | 0% |
| 2024 ACF Regionals @ Cornell | 01/27/2024 | Y | 3 | 16.67 | 100% | 67% | 0% |
| 2024 ACF Regionals @ JMU | 01/27/2024 | Y | 9 | 15.56 | 100% | 56% | 0% |
| 2024 ACF Regionals @ Minnesota | 01/27/2024 | Y | 2 | 20.00 | 100% | 100% | 0% |
| 2024 ACF Regionals @ Nebraska | 01/27/2024 | Y | 6 | 16.67 | 100% | 67% | 0% |
| 2024 ACF Regionals @ Rutgers | 01/27/2024 | Y | 5 | 20.00 | 100% | 80% | 20% |
| 2024 ACF Regionals @ Imperial | 01/27/2024 | Y | 4 | 20.00 | 100% | 100% | 0% |
Data
| Duke A (UG) | UNC D (DII) | 0 | 10 | 10 | 20 |
| UNC B (UG) | GWU A (UG) | 0 | 10 | 10 | 20 |
| Virginia C (UG) | GWU B (Grad) | 0 | 0 | 10 | 10 |
| Maryland A (Grad) | Liberty A (Grad) | 0 | 10 | 10 | 20 |
| Virginia B (UG) | Liberty C (DII) | 0 | 0 | 10 | 10 |
| Maryland C (DII) | JMU B (UG) | 0 | 0 | 10 | 10 |
| Liberty B (DII) | Roanoke College A (DII) | 0 | 0 | 10 | 10 |
| Virginia A (UG) | JMU A (UG) | 0 | 10 | 10 | 20 |
| UNC A (Grad) | William & Mary A (UG) | 0 | 10 | 10 | 20 |