SCENIC and CellOracle are methods used to screen perturbations of these proteins in vitro. The HOMER database uses position weight matrices to determine how consistently one of these proteins will bind to its given substrate. A class of these proteins that interact with inaccessible regions of their targets are called “pioneers.” The helix-loop-helix domain is a common characteristic of these (10[1])proteins, which can be pulled down by antibodies along with their substrate during ChIP. Six of these proteins fold together to form the pre-initiation complex. Similarity to the consensus sequence of these proteins determines the strength of genetic enhancers and promoters. For 10 points, name these DNA-binding proteins that impact recruitment of RNA polymerase to regulate the synthesis of mRNA. ■END■