Question
Cathepsin proteases generally only function within the low pH of this organelle. For 10 points each:
[10e] Name this organelle whose malfunction can cause “storage diseases” in which this organelle fails to break down unwanted material during autophagy.
ANSWER: lysosome [accept lysosomal storage diseases]
[10h] The “type C” variant of this lysosomal storage disease results from accumulation of cholesterol in cells, which then become “foamy.” Other forms of this disease result in the inability for cells to break down sphingomyelin (“sfing-go-MY-uh-lin”).
ANSWER: Niemann–Pick disease [or NP; accept Niemann–Pick disease type A, B, or C]
[10m] Proteins in the Golgi apparatus can be marked for transport to the lysosome by being tagged with a phosphorylated version of this sugar. This sugar is the C2 epimer of glucose.
ANSWER: mannose [accept mannose-6-phosphate; prompt on M6P]
<Biology>
Summary
| 2024 ACF Regionals @ Berkeley | 01/27/2024 | Y | 3 | 13.33 | 100% | 33% | 0% |
| 2024 ACF Regionals @ Cornell | 01/27/2024 | Y | 3 | 10.00 | 100% | 0% | 0% |
| 2024 ACF Regionals @ JMU | 01/27/2024 | Y | 10 | 10.00 | 70% | 30% | 0% |
| 2024 ACF Regionals @ Minnesota | 01/27/2024 | Y | 2 | 15.00 | 100% | 50% | 0% |
| 2024 ACF Regionals @ Ohio State | 01/27/2024 | Y | 3 | 13.33 | 100% | 33% | 0% |
| 2024 ACF Regionals @ Rutgers | 01/27/2024 | Y | 4 | 15.00 | 100% | 50% | 0% |
| 2024 ACF Regionals @ Imperial | 01/27/2024 | Y | 8 | 12.50 | 75% | 25% | 25% |
| 2024 ACF Regionals @ Vanderbilt | 01/27/2024 | Y | 5 | 20.00 | 100% | 80% | 20% |
| 2024 ACF Regionals @ MIT | 01/27/2024 | Y | 1 | 10.00 | 100% | 0% | 0% |
Data
| Warwick | Bristol | 10 | 0 | 0 | 10 |
| Imperial A | Cambridge A | 10 | 10 | 10 | 30 |
| Cambridge C | Kiel | 10 | 0 | 0 | 10 |
| Sheffield | Durham B | 0 | 0 | 0 | 0 |
| Edinburgh | Oxford B | 10 | 0 | 10 | 20 |
| Cambridge B | KCL | 0 | 0 | 0 | 0 |
| Oxford A | Imperial B | 10 | 10 | 0 | 20 |
| Oxford C | Durham A | 10 | 0 | 0 | 10 |