lysosome - 2024 ACF Regionals

Question

Cathepsin proteases generally only function within the low pH of this organelle. For 10 points each:

[10e] Name this organelle whose malfunction can cause “storage diseases” in which this organelle fails to break down unwanted material during autophagy.

ANSWER: lysosome [accept lysosomal storage diseases]

[10h] The “type C” variant of this lysosomal storage disease results from accumulation of cholesterol in cells, which then become “foamy.” Other forms of this disease result in the inability for cells to break down sphingomyelin (“sfing-go-MY-uh-lin”).

ANSWER: Niemann–Pick disease [or NP; accept Niemann–Pick disease type A, B, or C]

[10m] Proteins in the Golgi apparatus can be marked for transport to the lysosome by being tagged with a phosphorylated version of this sugar. This sugar is the C2 epimer of glucose.

ANSWER: mannose [accept mannose-6-phosphate; prompt on M6P]

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Summary


2024 ACF Regionals @ Berkeley	01/27/2024	Y	3	13.33	100%	33%	0%
2024 ACF Regionals @ Cornell	01/27/2024	Y	3	10.00	100%	0%	0%
2024 ACF Regionals @ JMU	01/27/2024	Y	10	10.00	70%	30%	0%
2024 ACF Regionals @ Minnesota	01/27/2024	Y	2	15.00	100%	50%	0%
2024 ACF Regionals @ Ohio State	01/27/2024	Y	3	13.33	100%	33%	0%
2024 ACF Regionals @ Rutgers	01/27/2024	Y	4	15.00	100%	50%	0%
2024 ACF Regionals @ Imperial	01/27/2024	Y	8	12.50	75%	25%	25%
2024 ACF Regionals @ Vanderbilt	01/27/2024	Y	5	20.00	100%	80%	20%
2024 ACF Regionals @ MIT	01/27/2024	Y	1	10.00	100%	0%	0%

Data


Iowa State	Arizona State	10	0	0	10
Minnesota B	Minnesota C	10	0	10	20
Ohio State A	Michigan B	10	0	10	20
Michigan C	Michigan A	10	0	0	10
Ohio State B	Cedarville	10	0	0	10
Brandeis A	Dartmouth A	10	0	0	10
Berkeley C	Berkeley B	10	0	10	20
Stanford A	Stanford C	10	0	0	10
Berkeley A	Stanford B	10	0	0	10
RIT A	Binghamton	10	0	0	10
Cornell A	Cornell C	10	0	0	10
Cornell B	RIT B	10	0	0	10
GWU A (UG)	William & Mary A (UG)	10	0	0	10
GWU B (Grad)	Duke A (UG)	0	0	0	0
JMU A (UG)	JMU B (UG)	10	0	0	10
Maryland C (DII)	Liberty B (DII)	0	0	0	0
Roanoke College A (DII)	Liberty C (DII)	0	0	0	0
UNC A (Grad)	Maryland A (Grad)	10	0	10	20
Maryland B (UG)	Virginia B (UG)	10	0	0	10
UNC B (UG)	UNC C (UG)	10	0	10	20
Virginia A (UG)	Liberty A (Grad)	10	0	0	10
Virginia C (UG)	UNC D (DII)	10	0	10	20
Warwick	Bristol	10	0	0	10
Imperial A	Cambridge A	10	10	10	30
Cambridge C	Kiel	10	0	0	10
Sheffield	Durham B	0	0	0	0
Edinburgh	Oxford B	10	0	10	20
Cambridge B	KCL	0	0	0	0
Oxford A	Imperial B	10	10	0	20
Oxford C	Durham A	10	0	0	10
Geodesic	Harding	10	10	10	30
Georgia Tech A	Tennessee	10	0	0	10
Kentucky	Alabama	10	0	10	20
MTSU	South Carolina	10	0	10	20
Georgia Tech B	Vanderbilt B	10	0	10	20
Haverford	Vassar	10	0	0	10
NYU A	Columbia A	10	0	0	10
Columbia B	NYU B	10	0	10	20
Johns Hopkins	Rowan	10	0	10	20