Question
MutH selectively nicks templates without this modification to distinguish the original from the newly synthesized strand in bacterial mismatch repair. For 10 points each:
[10m] Name this modification catalyzed in eukaryotes by DNMTs.
ANSWER: DNA methylation [accept equivalents that involve adding a methyl group]
[10h] This enzyme is used to methylate adenine residues following bacterial replication to protect against digestion by restriction enzymes. This methylase recognizes the sequence GATC.
ANSWER: DNA adenine methylase [or Dam; reject “DNA cytosine methylase” or “Dcm”]
[10e] Similar methylation patterns between parents and their children are studied in this field of biology. This field studies changes to an organism’s phenotype that are not caused by changes to their genomic DNA sequence.
ANSWER: epigenetics
<Biology>
Summary
| 2024 ACF Regionals @ Berkeley | 01/27/2024 | Y | 3 | 20.00 | 100% | 100% | 0% |
| 2024 ACF Regionals @ Cornell | 01/27/2024 | Y | 3 | 10.00 | 67% | 33% | 0% |
| 2024 ACF Regionals @ JMU | 01/27/2024 | Y | 9 | 11.11 | 89% | 22% | 0% |
| 2024 ACF Regionals @ Minnesota | 01/27/2024 | Y | 2 | 25.00 | 100% | 100% | 50% |
| 2024 ACF Regionals @ Ohio State | 01/27/2024 | Y | 3 | 16.67 | 100% | 67% | 0% |
| 2024 ACF Regionals @ Rutgers | 01/27/2024 | Y | 5 | 18.00 | 100% | 80% | 0% |
| 2024 ACF Regionals @ Imperial | 01/27/2024 | Y | 8 | 16.25 | 88% | 50% | 25% |
| 2024 ACF Regionals @ Vanderbilt | 01/27/2024 | Y | 5 | 14.00 | 60% | 60% | 20% |
| 2024 ACF Regionals @ MIT | 01/27/2024 | Y | 3 | 13.33 | 100% | 33% | 0% |
Data
| Bristol | Imperial A | 0 | 0 | 10 | 10 |
| Cambridge A | Oxford C | 10 | 10 | 10 | 30 |
| Edinburgh | Cambridge C | 0 | 0 | 0 | 0 |
| Imperial B | Oxford B | 10 | 0 | 10 | 20 |
| Oxford A | KCL | 0 | 10 | 10 | 20 |
| Kiel | Cambridge B | 10 | 0 | 10 | 20 |
| Sheffield | Durham A | 0 | 0 | 10 | 10 |
| Durham B | Warwick | 10 | 0 | 10 | 20 |