DNA methylation - 2024 ACF Regionals

Question

MutH selectively nicks templates without this modification to distinguish the original from the newly synthesized strand in bacterial mismatch repair. For 10 points each:

[10m] Name this modification catalyzed in eukaryotes by DNMTs.

ANSWER: DNA methylation [accept equivalents that involve adding a methyl group]

[10h] This enzyme is used to methylate adenine residues following bacterial replication to protect against digestion by restriction enzymes. This methylase recognizes the sequence GATC.

ANSWER: DNA adenine methylase [or Dam; reject “DNA cytosine methylase” or “Dcm”]

[10e] Similar methylation patterns between parents and their children are studied in this field of biology. This field studies changes to an organism’s phenotype that are not caused by changes to their genomic DNA sequence.

ANSWER: epigenetics

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Summary


2024 ACF Regionals @ Berkeley	01/27/2024	Y	3	20.00	100%	100%	0%
2024 ACF Regionals @ Cornell	01/27/2024	Y	3	10.00	67%	33%	0%
2024 ACF Regionals @ JMU	01/27/2024	Y	9	11.11	89%	22%	0%
2024 ACF Regionals @ Minnesota	01/27/2024	Y	2	25.00	100%	100%	50%
2024 ACF Regionals @ Ohio State	01/27/2024	Y	3	16.67	100%	67%	0%
2024 ACF Regionals @ Rutgers	01/27/2024	Y	5	18.00	100%	80%	0%
2024 ACF Regionals @ Imperial	01/27/2024	Y	8	16.25	88%	50%	25%
2024 ACF Regionals @ Vanderbilt	01/27/2024	Y	5	14.00	60%	60%	20%
2024 ACF Regionals @ MIT	01/27/2024	Y	3	13.33	100%	33%	0%

Data


Virginia B (UG)	Duke A (UG)	0	0	10	10
UNC D (DII)	GWU A (UG)	0	0	10	10
William & Mary A (UG)	GWU B (Grad)	0	0	10	10
JMU A (UG)	Virginia C (UG)	0	0	10	10
Liberty A (Grad)	Maryland C (DII)	0	0	10	10
Virginia A (UG)	Liberty B (DII)	0	0	10	10
Liberty C (DII)	Maryland A (Grad)	0	0	0	0
MTSU	Alabama	10	0	0	10
Geodesic	Georgia Tech B	10	0	10	20
Vanderbilt A	Harding	10	10	10	30
Maryland B (UG)	Roanoke College A (DII)	10	0	10	20
UNC B (UG)	JMU B (UG)	10	0	10	20
Iowa State	Minnesota B	10	0	10	20
Arizona State	Minnesota C	10	10	10	30
Kenyon	Cedarville	10	0	10	20
Michigan C	Michigan A	0	0	10	10
Ohio State A	Ohio State B	10	0	10	20
South Carolina	Tennessee	0	0	0	0
Georgia Tech A	Vanderbilt B	0	0	10	10
Brandeis A	Boston University	10	0	10	20
Dartmouth A	Brandeis B	0	0	10	10
Harvard B	Yale A	0	0	10	10
Berkeley A	Berkeley B	10	0	10	20
Stanford B	Berkeley C	10	0	10	20
Stanford A	Stanford C	10	0	10	20
Cornell A	Binghamton	0	0	0	0
Cornell B	Cornell C	0	0	10	10
RIT B	RIT A	10	0	10	20
Columbia A	NYU B	10	0	10	20
Haverford	Columbia C	10	0	10	20
NYU A	John Jay	0	0	10	10
Penn	Columbia B	10	0	10	20
Vassar	Rowan	10	0	10	20
Bristol	Imperial A	0	0	10	10
Cambridge A	Oxford C	10	10	10	30
Edinburgh	Cambridge C	0	0	0	0
Imperial B	Oxford B	10	0	10	20
Oxford A	KCL	0	10	10	20
Kiel	Cambridge B	10	0	10	20
Sheffield	Durham A	0	0	10	10
Durham B	Warwick	10	0	10	20