One of these molecules is the substrate of soluble liver antigen, a target of autoimmune hepatitis. Modification of the Levitt pair changes which “identity set” these molecules are part of. The high fidelity of the synthesis and subsequent recognition of these kilodalton-sized molecules motivated the theory of kinetic proofreading. Orthogonal systems for processing these molecules are often based on M. jannaschii’s reduced set of synthases and can ligate them with “unnatural” components. TetM and TetO are “protectors” that help these molecules bind in the presence of tetracyclines and have homology to EF-Tu. Each of these L-shaped molecules is paired with an AARS that “charges” them with a specific zwitterion before they enter the A site. For 10 points, name these molecules that enter the ribosome carrying the amino acid for a given codon. ■END■
ANSWER: tRNAs [or transfer RNAs; accept aminoacyl-tRNA, aa-tRNAs, charged tRNAs, or loaded tRNAs; prompt on RNA or ribonucleic acid] (Soluble liver/pancreas antigen adds selenium to phosphoserine-tRNA to form selenocysteine-tRNA.)
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= Average correct buzz position