Question

Cells performing this process have a chance to kill themselves by targeting “like S-gamma” regions past the alpha-2 exon, which will “loop out” an entire locus. Errors in this process cause translocation of c-myc [emphasize] downstream of J sub H, the most common mutation (-5[1])in Burkitt lymphoma. (-5[2])This process excises a ring of DNA with up to seven exons preceding the C-alpha gene. (-5[1])S-regions are joined together during this process, (-5[1])which borrows endonucleases (“endo-NOO-klee-aces”) from base excision repair to cleave abasic (-5[2])(“AY-basic”) sites formed by cytidine deaminase (“dee-AM-in-ace”), diverting them from somatic hypermutation. (-5[2])This process (-5[1])follows VDJ (-5[1])recombination (-5[1])in an activated B (-5[1])cell and can change the expressed constant region from mu to gamma-3 or gamma-1. For 10 (10[1])points, name this (-5[1])process that swaps out the heavy chain to allow expression of immunoglobulins other than IgM. (0[1])■END■ (10[3]0[11])

ANSWER: class switching [or class switch recombination; accept CSR, isotype switching, isotype recombination, or isotypic commutation; prompt on recombination; prompt on changing isotype or changing antibody class by asking “what is the name of that process?”; reject “VDJ recombination”]
<Biology>
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Summary

2024 ACF Nationals2024-04-21Y2218%0%64%128.25

Buzzes

PlayerTeamOpponentBuzz PositionValue
Moses KitakuleColumbia AWaterloo43-5
David BassJohns HopkinsNorthwestern46-5
Andrew WangIllinoisMichigan46-5
Ben WeinerMinnesota AChicago B62-5
Bryan UgazArizona StateColumbia B69-5
Rasheeq AzadNorth Carolina BSouth Carolina79-5
Ryan HumphreyTexasCornell A79-5
Michal GerasimiukStanfordWUSTL A89-5
Amith PunyalaWUSTL BVirginia89-5
Yashodev VyasMinnesota BChicago C91-5
Jason HongBrownNYU93-5
Akshay SeetharamClaremont CollegesToronto B94-5
Kushal AluruRutgersPenn98-5
Raymond ChenToronto AYale A11410
Adam FineChicago AIndiana117-5
Anirudh BharadwajPennRutgers1320
Yared TadesseCornell BBerkeley B1330
Rohan ShelkeBerkeley BCornell B1330
Albert ZhangColumbia BArizona State1330
Ashish SubramanianDukeOttawa1330
Graham CopeFloridaYale B13310
Shahar SchwartzBerkeley AGeorgia Tech1330
Alex AkridgeIndianaChicago A1330
Caleb KendrickMarylandIowa State13310
Jason HuangNorthwesternJohns Hopkins1330
Cory SmithKentuckyTruman State1330
Yashwanth BajjiMichiganIllinois1330
Henry CafaroChicago BMinnesota A1330
Vincent DuNorth Carolina APurdue1330
Paul LeeWUSTL AStanford13310