Cells performing this process have a chance to kill themselves by targeting “like S-gamma” regions past the alpha-2 exon, which will “loop out” an entire locus. Errors in this process cause translocation of c-myc [emphasize] downstream of J sub H, the most common mutation in Burkitt lymphoma. This process excises a ring of DNA with up to seven exons preceding the C-alpha gene. S-regions are joined together during this process, which borrows endonucleases (“endo-NOO-klee-aces”) from base excision repair to cleave abasic (“AY-basic”) sites formed by cytidine deaminase (“dee-AM-in-ace”), diverting them from somatic hypermutation. This process follows VDJ recombination in an activated B cell and can change the expressed constant region from mu to gamma-3 or gamma-1. For 10 points, name this process that swaps out the heavy chain to allow expression of immunoglobulins other than IgM. ■END■
ANSWER: class switching [or class switch recombination; accept CSR, isotype switching, isotype recombination, or isotypic commutation; prompt on recombination; prompt on changing isotype or changing antibody class by asking “what is the name of that process?”; reject “VDJ recombination”]
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= Average correct buzz position