Question

Thap·si·gar·gin and tunic·a·mycin can be used in research to activate this system, which is thought to involve assembly of a protein complex called the “[this system]-osome.” For 10 points each:
[10h] Name this cellular system, which is activated by 3 sensors: ATF6, PERK, and IRE1. Activation of this system may activate downstream pathways such as ERAD or autophagy.
ANSWER: unfolded protein response [or the UPR; accept UPRosomes]
[10e] The unfolded protein response is activated by stress to this organelle, the main site of protein folding.
ANSWER: endoplasmic reticulum [accept rough endoplasmic reticulum or rough ER]
[10m] Tunicamycin causes ER stress by inhibiting this specific process. The name of this process references the specific atom on an asparagine residue to which acetyl·glucos·amine and mannose molecules are transferred en bloc from dolichol phosphate.
ANSWER: N-linked glycosylation [prompt on glycosylation]
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2023 BHSU @ Northwestern02/25/2023Y611.6750%50%17%

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Amartya Senpai Notice MeWUSTL10101030
Chicago BNorthwestern0000
Epic GamesMojo Shojo0101020
Illinois+Ohio State0000
Chicago APurdue0101020
Maryland B-Michigan0000