Question
Thap·si·gar·gin and tunic·a·mycin can be used in research to activate this system, which is thought to involve assembly of a protein complex called the “[this system]-osome.” For 10 points each:
[10h] Name this cellular system, which is activated by 3 sensors: ATF6, PERK, and IRE1. Activation of this system may activate downstream pathways such as ERAD or autophagy.
ANSWER: unfolded protein response [or the UPR; accept UPRosomes]
[10e] The unfolded protein response is activated by stress to this organelle. It’s the main site of protein folding and is continuous with the nuclear envelope.
ANSWER: endoplasmic reticulum [accept rough endoplasmic reticulum or rough ER]
[10m] Tunicamycin causes ER stress by inhibiting this specific process. The name of this process references the specific atom on an asparagine residue to which acetyl·glucos·amine and mannose molecules are transferred en bloc from dolichol phosphate.
ANSWER: N-linked glycosylation [prompt on glycosylation]
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Summary
| 2023 BHSU @ Berkeley | 03/18/2023 | Y | 3 | 20.00 | 100% | 67% | 33% |
| 2023 BHSU @ Maryland | 03/11/2023 | Y | 3 | 16.67 | 100% | 67% | 0% |
| 2023 BHSU Online | 04/15/2023 | Y | 4 | 20.00 | 100% | 50% | 50% |
| 2023 BHSU @ Sheffield | 04/15/2023 | Y | 2 | 5.00 | 50% | 0% | 0% |
| 2023 BHSU @ Waterloo | 04/15/2023 | Y | 3 | 13.33 | 100% | 33% | 0% |
Data
| Neg 5! Playing Quizbowl, Liddy Style | Parth et al. | 0 | 10 | 0 | 10 |
| The Passion According to C.H. | Milan et al. | 0 | 10 | 10 | 20 |
| Cameron et al. | The Vulture's Guide to Buzz | 0 | 10 | 0 | 10 |