Question

When determining whether a drug analog is worth synthesizing, medicinal chemists may use software to compute this function of the drug’s partition coefficient. For 10 points each:
[10e] Name this function of the partition coefficient that is below plus-five for orally active drugs. The negative of this function is used to determine a solution’s pH from its concentration of protons.
ANSWER: logarithm [or log]
[10m] The cLogP (“c-log-P”) of a drug is important for this property of orally active drugs, which can be quantified with a variable labeled F. This property is the fraction of an administered drug that reaches systemic circulation.
ANSWER: bioavailability [accept oral availability]
[10h] Veber’s parameters define criteria for predicting good bioavailability for orally active drugs. One of the required criteria involves ten or fewer of these entities, which are [emphasize] not exemplified by amide C–N bonds.
ANSWER: rotatable bonds [accept answers indicating bonds that allow rotation or can rotate]
<JZ, Chemistry>

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Summary

Data

Cornell MATLABCornell R100010
Syracuse+RochesterRIT1010020