Question
When determining whether a drug analog is worth synthesizing, medicinal chemists may use software to compute this function of the drug’s partition coefficient. For 10 points each:
[10e] Name this function of the partition coefficient that is below plus-five for orally active drugs. The negative of this function is used to determine a solution’s pH from its concentration of protons.
ANSWER: logarithm [or log]
[10m] The cLogP (“c-log-P”) of a drug is important for this property of orally active drugs, which can be quantified with a variable labeled F. This property is the fraction of an administered drug that reaches systemic circulation.
ANSWER: bioavailability [accept oral availability]
[10h] Veber’s parameters define criteria for predicting good bioavailability for orally active drugs. One of the required criteria involves ten or fewer of these entities, which are [emphasize] not exemplified by amide C–N bonds.
ANSWER: rotatable bonds [accept answers indicating bonds that allow rotation or can rotate]
<JZ, Chemistry>
Summary
| 2023 ARCADIA at UC Berkeley | Premiere | Y | 2 | 15.00 | 100% | 50% | 0% |
| 2023 ARCADIA at Carleton University | Premiere | Y | 2 | 15.00 | 50% | 100% | 0% |
| 2023 ARCADIA at Claremont Colleges | Premiere | Y | 1 | 20.00 | 100% | 100% | 0% |
| 2023 ARCADIA at Duke | Emory, Duke, Yale | Y | 3 | 6.67 | 67% | 0% | 0% |
| 2023 ARCADIA at Emory | Emory, Duke, Yale | Y | 3 | 10.00 | 67% | 33% | 0% |
| 2023 ARCADIA at Imperial | Imperial | Y | 5 | 8.00 | 60% | 20% | 0% |
| 2023 ARCADIA at Indiana | Premiere | Y | 3 | 16.67 | 67% | 100% | 0% |
| 2023 ARCADIA at Maryland | Maryland, Online | Y | 2 | 5.00 | 50% | 0% | 0% |
| 2023 ARCADIA at Ohio State | Ohio State, Texas | Y | 3 | 3.33 | 33% | 0% | 0% |
| 2023 ARCADIA Online | Maryland, Online | Y | 3 | 13.33 | 67% | 67% | 0% |
| 2023 ARCADIA at RIT | Premiere | Y | 2 | 15.00 | 100% | 50% | 0% |
| 2023 ARCADIA at Texas | Ohio State, Texas | Y | 3 | 13.33 | 100% | 33% | 0% |
| 2023 ARCADIA at WUSTL | Premiere | Y | 3 | 6.67 | 33% | 33% | 0% |
Data
| Kenyon B | Michigan B | 0 | 0 | 0 | 0 |
| Ohio State A | Michigan A | 10 | 0 | 0 | 10 |
| Ohio State B | Kenyon A | 0 | 0 | 0 | 0 |