superantigens - 2023 ARCADIA at Texas

Question

These molecules bind to the V-beta chain of T-cell receptors, giving them a greater number of potential targets than those restricted to unique alpha and beta receptor clonotypes. For 10 points each:

[10h] Name these molecules that bind class II MHCs and T-cell receptors outside of the normal peptide-binding groove, resulting in T-cell overactivation. These molecules act as potent exotoxins in scarlet fever.

ANSWER: superantigens [accept SAgs; prompt on antigens]

[10e] Superantigen engagement causes T-cells to activate signaling through the Src (“sark”) family of kinases, which are enzymes that transfer these groups from donors like ATP to their substrates.

ANSWER: phosphates

[10m] In the absence of a Src kinase, SAgs activate T-cells through the activation of phospholipase C by the alpha-11 subunit of these proteins. These proteins couple with receptors that cross the cell membrane seven times.

ANSWER: G proteins [or guanine-nucleotide-binding proteins; accept heterotrimeric G proteins]

<AY, Biology>

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Summary


2023 ARCADIA at Duke	Emory, Duke, Yale	Y	4	2.50	25%	0%	0%
2023 ARCADIA at Emory	Emory, Duke, Yale	Y	4	10.00	100%	0%	0%
2023 ARCADIA at Imperial	Imperial	Y	5	10.00	60%	40%	0%
2023 ARCADIA at Maryland	Maryland, Online	Y	3	10.00	67%	33%	0%
2023 ARCADIA at Ohio State	Ohio State, Texas	Y	3	13.33	67%	67%	0%
2023 ARCADIA Online	Maryland, Online	Y	3	6.67	67%	0%	0%
2023 ARCADIA at Texas	Ohio State, Texas	Y	3	10.00	67%	33%	0%
2023 BHSU @ Berkeley	03/18/2023	N	3	16.67	100%	67%	0%
2023 BHSU @ Maryland	03/11/2023	N	2	20.00	100%	100%	0%
2023 BHSU @ Northwestern	02/25/2023	N	6	18.33	100%	83%	0%
2023 BHSU Online	04/15/2023	N	4	17.50	100%	75%	0%
2023 BHSU @ Sheffield	04/15/2023	N	2	10.00	100%	0%	0%
2023 BHSU @ Waterloo	04/15/2023	N	2	15.00	100%	50%	0%

Data


HCC	Texas B	10	0	10
TAMU	TAG Magnet: Taylor's Version	0	0	0
Texas A	Texas C	10	10	20