Question
Drugs that are oxidized by these enzymes are often sold with a label warning "Do not take with grapefruit juice." For 10 points each:
[10h] Name these heme-containing enzymes that perform Phase I (“one”) metabolism of about 80 percent of all clinically available drugs. They are named for their absorption peak when bound to carbon monoxide.
ANSWER: cytochrome P450s (“P-four-fiftys”) [or CYPs; or P450s; or CYP450s; or cytochrome P450 monooxygenases; prompt on cytochromes or monooxygenases or oxidoreductases]
[10e] Most first-pass drug metabolism by cytochrome P450s, or CYPs (“sips”), occurs in this digestive organ which has four lobes and is fed by the hepatic portal vein.
ANSWER: liver
[10m] Grapefruit juice usually doesn’t affect drugs administered in this manner since they avoid first-pass metabolism by CYPs. This parenteral route of administration is the fastest way to deliver drugs as it requires no absorption and has 100 percent bioavailability.
ANSWER: intravenous [or IV; accept intravascular; accept intraarterial; accept intraosseus; accept descriptions of administration directly into the bloodstream or circulatory system; prompt on injection or shot; reject “intramuscular”]
<Biology>
Summary
| 2023 ACF Winter @ Columbia | 11/11/2023 | Y | 9 | 15.56 | 56% | 89% | 11% |
Data
| Bard A | Columbia C | 0 | 0 | 10 | 10 |
| Columbia A | Cornell C | 0 | 10 | 10 | 20 |
| NYU A | Princeton A | 0 | 0 | 10 | 10 |
| Rowan A | NYU B | 0 | 0 | 10 | 10 |
| Rutgers B | Penn A | 0 | 0 | 10 | 10 |
| Princeton B | Haverford | 0 | 10 | 0 | 10 |
| Rutgers A | Columbia B | 0 | 10 | 10 | 20 |
| Yale A | Vassar | 10 | 10 | 10 | 30 |
| Penn B | Yale C | 0 | 10 | 10 | 20 |