Question
Points that lie above a horizontal threshold on one of these plots typically have a minor allele frequency of at least 5 percent. For 10 points each:
[10h] Name these plots that display chromosomal coordinates on the x-axis and the negative log of the P-value on the y-axis.
ANSWER: Manhattan plots
[10e] Manhattan plots are used in a type of study looking for associations across this construct. This term refers to the entire set of genetic material in an organism, which was completely mapped for Homo sapiens by a global sequencing project completed in 2003.
ANSWER: genome [accept Human Genome Project; accept genome-wide association study; prompt on GWAS]
[10m] Each dot on a Manhattan plot represents one of these substitutions, which are changes in a single position of DNA that are present in at least 1 percent of the population.
ANSWER: SNPs (“snips”) [or single nucleotide polymorphisms; prompt on variants or single nucleotide variants or SNVs or polymorphisms or alleles; reject “mutations”]
<Biology>
Summary
| 2023 ACF Winter @ Columbia | 11/11/2023 | Y | 9 | 12.22 | 89% | 33% | 0% |
Data
| Columbia A | Haverford | 0 | 10 | 0 | 10 |
| Columbia B | Rowan A | 0 | 10 | 0 | 10 |
| Princeton A | Columbia C | 0 | 10 | 0 | 10 |
| Penn A | Cornell C | 0 | 10 | 10 | 20 |
| Bard A | NYU A | 0 | 0 | 0 | 0 |
| Yale B | Rutgers A | 0 | 10 | 10 | 20 |
| Princeton B | Rutgers B | 0 | 10 | 0 | 10 |
| Penn B | Vassar | 0 | 10 | 0 | 10 |
| Yale A | Yale C | 0 | 10 | 10 | 20 |