Question
In the Providence mutant of this protein, its lysine EF6 residue is replaced by an asparagine residue, causing its affinity for 2,3-diphosphoglycerate (“two-three-di-phospho-glycerate”) to decrease. For 10 points each:
[10e] Name this iron-containing protein found in red blood cells that transports oxygen through the human body.
ANSWER: hemoglobin [accept Hb or Hgb; prompt on heme]
[10m] Oxygen’s binding affinity to hemoglobin is affected by pH and this dependent variable, according to the Bohr effect. A higher value of this variable leads to more bicarbonate formation, in turn changing the blood pH.
ANSWER: carbon dioxide concentration [accept CO2 concentration]
[10h] Iron centers in heme are stabilized by ligands of this compound, which bind the heme to the rest of hemoglobin. The amino acid with this heterocyclic compound as a side chain is positively charged at physiological pH.
ANSWER: imidazoles (“ih-MIDE-uh-zoles”) [accept 1,3-diazoles; prompt on histidine or His]
<Chemistry>
Summary
| 2023 ACF Winter @ Columbia | 11/11/2023 | Y | 9 | 14.44 | 100% | 33% | 11% |
Data
| NYU A | Cornell C | 10 | 0 | 0 | 10 |
| Vassar | NYU B | 10 | 0 | 0 | 10 |
| Penn A | Rowan A | 10 | 0 | 10 | 20 |
| Princeton A | Haverford | 10 | 10 | 0 | 20 |
| Bard A | Princeton B | 10 | 0 | 0 | 10 |
| Rutgers B | Yale C | 10 | 0 | 0 | 10 |
| Yale A | Rutgers A | 10 | 10 | 0 | 20 |
| Yale B | Penn B | 10 | 10 | 0 | 20 |
| Columbia B | Columbia A | 10 | 0 | 0 | 10 |