Question
An antibiotic from this class is the first-line therapy for a number of zoonotic (“zoh-uh-NOT-ick”) diseases, including Lyme disease, plague, and Q fever. For 10 points each:
[10m] Name this class of bacteriostatic antibiotics. Like aminoglycosides, these drugs bind the 30S (“thirty-S”) ribosomal subunit to inhibit charged tRNAs from entering the A site, halting translation.
ANSWER: tetracyclines (“teh-truh-CY-cleens”) [or tetracycline antibiotics; prompt on doxycycline]
[10e] Tetracycline resistance underlies Tet-On and Tet-Off, paradigms that use tetracycline transactivators and response elements to control this process. Promoters in DNA recruit RNAPII (“R-N-A-P-two”) to initiate this process.
ANSWER: transcription [accept gene expression; accept tetracycline-controlled transcriptional activation]
[10h] Tet transactivators for transcriptional control generate less of this side effect than transactivators like VP16. This effect occurs when strong expression of a transactivator inhibits the expression of other genes.
ANSWER: squelching [or transcriptional squelching; or word forms of squelch]
<Biology>
Summary
| 2023 ACF Nationals | 04/22/2023 | Y | 7 | 14.29 | 100% | 43% | 0% |
Data
| Cornell A | Imperial A | 10 | 10 | 0 | 20 |
| Chicago B | Iowa State A | 0 | 10 | 0 | 10 |
| South Carolina A | Florida A | 0 | 10 | 0 | 10 |
| Chicago A | Minnesota A | 0 | 10 | 0 | 10 |
| Ohio State A | Texas A | 10 | 10 | 0 | 20 |
| Georgia Tech A | Illinois A | 0 | 10 | 0 | 10 |
| Northwestern A | Claremont A | 10 | 10 | 0 | 20 |