PKU - 2025 Penn Bowl - Buzzpoints App

Question

The first approved newborn genetic test, a bacterial assay developed by Robert Guthrie, was used to screen for this disease. For 10 points each:

[10m] Name this autosomal recessive disease caused by a defect in the enzyme PAH. People with this disease are unable to metabolize phenyl·alanine and are advised not to consume the artificial sweetener aspartame.

ANSWER: PKU [or phenylketonuria; accept phenylketonurics; accept Følling disease]

[10h] Adding the blood of a sufferer of PKU to media containing bacteria of this genus promotes its proliferation in a Guthrie test. A member of this genus names a group of serine proteases commonly employed as a stain remover.

ANSWER: Bacillus [accept Bacillus subtilis; prompt on subtilisins by asking “what genus generates that enzymes?”]

[10e] Before Guthrie developed his namesake test, PKU was informally screened by reacting this substance with ferric chloride. The bladder stores this liquid substance before micturition.

ANSWER: urine [or pee; or piss; reject “urea”]

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Summary


2025 Penn Bowl - BU	11/01/25	Y	4	12.50	100%	25%	0%
2025 Penn Bowl - CWRU	11/01/25	Y	3	13.33	100%	33%	0%
2025 Penn Bowl - Mainsite (UPenn)	11/01/25	Y	6	15.00	100%	50%	0%
2025 Penn Bowl - Murray State	11/08/25	Y	2	15.00	100%	50%	0%
2025 Penn Bowl - Northwestern	10/25/25	Y	4	20.00	100%	75%	25%
2025 Penn Bowl - Online	11/08/25	Y	2	5.00	50%	0%	0%
2025 Penn Bowl - Ottawa	11/01/25	Y	7	17.14	100%	57%	14%
2025 Penn Bowl - Stanford	10/25/25	Y	4	20.00	100%	100%	0%
2025 Penn Bowl - UK	11/01/25	Y	9	14.44	100%	44%	0%
2025 Penn Bowl - UNC	11/01/25	Y	3	13.33	67%	67%	0%
2025 Penn Bowl - WashU	11/01/25	Y	2	20.00	100%	100%	0%

Data


I've been running into you in my lead plumbocene what could have benzene	Brown	0	0	10	10
RIT	MIT A	0	0	10	10
MIT B	Harvard	10	0	10	20
Brandeis	Yale	0	0	10	10
Michigan A	Michigan C	10	0	10	20
Ohio State A	Ohio State B	0	0	10	10
Michigan B	Pittsburgh	0	0	10	10
Maryland B	Columbia A	0	0	10	10
NYU B	JHU A	10	0	10	20
John Jay	Maryland C	10	0	10	20
Maryland A	Columbia B	10	0	10	20
JHU B	NYU A	0	0	10	10
Swarthmore	Mount Sinai	0	0	10	10
Texas B	Oklahoma	10	0	10	20
Texas A	Central Oklahoma	0	0	10	10
Northwestern B	Illinois	10	0	10	20
Indiana	Purdue A	10	10	10	30
Purdue B	UChicago C	0	0	10	10
UChicago B	UChicago A	10	0	10	20
Wake Up Paddington A Washington Mystery	New Young Whigs of America	0	0	10	10
rusty shackleford	abg academy	0	0	0	0
Aweille Kevin Fan osti continue comme ça	Toronto Sunshine Bubbles	0	0	10	10
Carleton A	McGill Fartlets	0	0	10	10
McGill B	Toronto G	10	0	10	20
Toronto Operation PBSuccess	Ottawa 67s	10	0	10	20
Queen's is monitoring the situation	#OpenToBuzz	0	0	10	10
Guelph perfomative male competition	Toronto Murder on the Rider Express	10	10	10	30
Waterloo you are crooked	Toronto E	10	0	10	20
In Search of Lost Clues	Berkeley A	10	0	10	20
Free Win	Berkeley B	10	0	10	20
The best time to buzz was twenty clues ago. The second best time to buzz is now	Stanford A	10	0	10	20
Berkeley C	Stanford B	10	0	10	20
Chimp Brisket	Bristold	0	0	10	10
Galactic Ombudsmen	Coughing Baby	0	0	10	10
1. Wawa 2. Blank Street 151. Black Sheep at Kings Cross rail	Hail to the Sheaf	0	0	10	10
Of Mice and Penn	Paul Quifford, or, It Was a Dark and Stormy Tournament	0	0	10	10
Penn and the Art of Tossup-Bonus cycle Maintenance	Quiztian Bale in Ratman Begins	10	0	10	20
The Bit and the Penndulum	Knorr Stock Clue	0	0	10	10
To buzz is to be perceived	Alas poor Warwick, I knew him Edinburgh	10	0	10	20
Washed Scrubs	question mark	10	0	10	20
Burnaburiash's Lapis Lazuli	why is it called a score clue if nobody scores points on it	10	0	10	20
Wise Duke	Planck Sinatra	10	0	10	20
UNC B	UNC A	0	0	0	0
VT A	VT B	10	0	10	20
WashU Bouba	VJ Edgecombe School of Interior Design - Edwardsville	10	0	10	20
Truman State	WashU Kiki	10	0	10	20