Question

“Spreading factors” that degrade this molecule increase the motility of members of Clostridium (“claw-strid-ee-um”), Streptococcus (“strep-toh-kok-us”), and Staphylococcus (“staff-ih-loh-kok-us”) in tissue. Low molecular weight fragments of this molecule are pro-inflammatory and angiogenic, (-5[1])while high molecular weight types are immunosuppressive and anti-angiogenic. BX7B motifs bind this molecule in receptors like RHAMM (“ram”) and CD44 (“C-D-forty-four”), which mediates its rapid turnover. This molecule in the corona radiata is degraded by an enzyme (10[1])released during the acrosomal reaction. Fillers like Restylane (“rest-al-in”) and Juvederm (“joov-eh-derm”) consist mostly of this molecule, (-5[2])as do injections for knee (10[1])pain (-5[1])due to (-5[1])osteoarthritis. (-5[2])This (10[1])polymer consists of units of (-5[1])glucuronic acid and N-acetylglucosamine (10[2]-5[2])(“N-ah-SEE-til-glue-KOS-ah-meen”), and it is a main component of lubricants like synovial fluid. For 10 points, name this only non-sulfated glycosaminoglycan (10[2])(“gly-kos-ah-meen-oh-gly-can”) often included (10[1]-5[2])in “hydrating” skincare formulations. (10[1])■END■ (10[6]0[4])

ANSWER: hyaluronic acid [or hyaluronan; accept native hyaluronic acid, accept low molecular weight hyaluronic acid, accept high molecular weight hyaluronic acid; prompt on any of HA, LMW-HA, or HMW-HA]
<Biology>
= Average correct buzz position

Summary

2023 ACF Nationals04/22/2023Y2365%0%52%110.20

Buzzes

PlayerTeamOpponentBuzz PositionValue
Ameya PhadnisRutgers BMichigan A28-5
Daniel SheinbergYale AGeorgia Tech A6410
Eric WolfsbergStanford AChicago A79-5
Jonathan LauJohns Hopkins APurdue A79-5
Karan GurazadaTexas AMIT A8410
Charles HangWUSTL AChicago B85-5
Nikhil ChellamNorthwestern AHarvard A87-5
Matthew SiffYale BVirginia A88-5
Henry CafaroChicago CIndiana A88-5
Andrew HannaVanderbilt ANYU A8910
Joelle SmartRutgers AClaremont A94-5
Jacob EgolDuke AFlorida A9810
Enoch YuenImperial AMinnesota B98-5
Raymond ChenToronto ANorth Carolina A9810
Julian GatchSouth Carolina APenn State A98-5
Geoffrey ChenCornell ABrown A11710
Noah ChenColumbia BFlorida B11710
Shahar SchwartzUC Berkeley ACornell B119-5
Pranav SivaramOhio State AMaryland A119-5
Vishal KanigicherlaPenn AWUSTL B11910
Mazin OmerHarvard ANorthwestern A12310
Vinu HariharUC Berkeley BHouston A1240
Adam FineChicago AStanford A12410
Jacob Van OorschotMcGill AIllinois A12410
Matt SchiavonePurdue AJohns Hopkins A12410
Todd MaslykMichigan ARutgers B1240
Dan NiCornell BUC Berkeley A12410
John BroussardHouston AUC Berkeley B1240
S. A. ShenoyGeorgia Tech BIowa State A12410
Daniel YangChicago BWUSTL A12410
Caleb KendrickMaryland AOhio State A1240