Question
A molecule with this structure was used by James Stoddart to create artificial “molecule muscles” that mimic the actions of myosin and actin. For 10 points each:
[10h] Name this mechanically interlocked architecture that consists of a dumbbell-shaped molecule threaded through a macrocycle. Molecules with this structure can be synthesized through clipping, capping, slipping, and snapping.
ANSWER: rotaxanes
[10m] This effect is why the inner thread of a rotaxane is stable. This effect is also why the bulkier tert-butyl bromide is more likely than methyl bromide to undergo an SN1 reaction.
ANSWER: steric hindrance [or steric effects]
[10e] Recent applications of rotaxanes have involved using them as nanovalves to deliver these compounds into the human body. These compounds may be classified by their mechanism of action or mode of action by the FDA.
ANSWER: drugs [or medicine]
<Berkeley A, Chemistry>
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