A form of therapy for this process can be used to sequester and remove heavy ions from the body. For 10 points each:
[10m] Name this process in which a ligand “bites” onto more than one location on a metal atom. Agents for this process include EDTA.
ANSWER: chelation [or word forms like chelate; prompt on coordination or bonding]
[10e] Chelation therapy can be used when patients are exposed to this heavy metal that interacts with enzymatic sulfur groups. A tetraethyl derivative of this element was added to gasoline to prevent engine knocking.
ANSWER: lead [accept leaded gasoline; accept Pb]
[10h] Protein purification may exploit the chelation activity of this side chain with nickel affinity columns. Metalloproteins may use a brace named for an amino acid containing this organic molecule.
ANSWER: imidazole [prompt on histidine by asking “what moiety makes up the side chain?”]
<CWRU D, Chemistry>