Staci Bilbo’s lab found that these cells shape social play behavior by eliminating D1 dopamine receptors in male but not female rats. In TREM-2-deficient Alzheimer’s mouse models, these cells lack a DAM profile. Starting 3 to 5 days post-necrosis, stroke histology is mainly characterized by these cells once they lose their ramified morphology. These IBA1-positive, CD45-negative cells self-sacrifice via necroptosis after cannibalizing each other’s debris. Biologists now use terms like “neurodegenerative” and (*) “disease-associated” to classify these [emphasize] specific cells’ activated versus resting states, instead of their broader cell type’s M1 and M2 classes. Unlike the neuroectoderm, the yolk sac yields these protective cells in Ramón y Cajal’s “third element” that provide immune surveillance. For 10 points, name these resident brain macrophages. ■END■
ANSWER: microglia [prompt on glia or glial cells; prompt on macrophages; prompt on monocytes] (The first clue refers to synaptic pruning in the nucleus accumbens.)
<AY, Biology>
= Average correct buzz position