Answer the following about David Goodsell’s watercolor paintings of cells, for 10 points each.
[10e] Goodsell first demonstrated his technique as a postdoc by illustrating this bacterium, which can cause traveler’s diarrhea. DH5-alpha and other benign strains of this bacterium are used to clone plasmids.
ANSWER: E. coli [or Escherichia coli]
[10m] Goodsell has created many images for the “Molecule of the Month” series at this project, whose entry “Ebola Virus” won him a Wellcome Image Award. This database is funded by the Research Collaboratory for Structural Bioinformatics.
ANSWER: Protein Data Bank [or PDB; accept Worldwide Protein Data Bank or wwPDB]
[10h] A dark green adherens junction disassembles in Goodsell’s image of a signaling pathway driven by these proteins. Genentech’s drug bevacizumab inhibits the “A” type of these proteins, whose levels are deficient in pre·eclampsia.
ANSWER: VEGFs (“veg-f”) [or vascular endothelial growth factors; accept VEGF-A; prompt on growth factors or GFs; prompt on VPFs or vascular permeability factors by asking “what are they called now?”; prompt on placental growth factor or PlGF by asking “what broader family of growth factors does that belong to?”]
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