Question
Answer the following about the relationship between a particular physiologic state and neurodegeneration, for 10 points each.
[10e] Disruption of the slow wave stage of this state is associated with increased CSF amyloid beta, suggesting a relationship between this state and Alzheimer’s. Growth hormone is secreted primarily during this state.
ANSWER: sleep [accept slow wave sleep; accept deep sleep]
[10m] Kang et al. found that infusion of almorexant, a dual receptor antagonist of this wakefulness hormone, reduced plaque burden in a mouse model of Alzheimer’s. Decreased levels of this hormone are associated with narcolepsy.
ANSWER: orexin [or hypocretin]
[10h] In another example of the relationship between sleep and neurodegeneration, Parkinson’s patients will prodromally exhibit this parasomnia, in which they experience vivid nightmares and act out their dreams.
ANSWER: REM sleep behavior disorder [or RBD; or RSBD; or rapid eye movement sleep behavior disorder]
<Yang, Biology>
Summary
| 2024 ESPN @ Brown | 04/06/2024 | Y | 3 | 16.67 | 100% | 67% | 0% |
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