The release of this ion from the N-lobe of a protein that binds to it is mediated by a pair of hydrogen bonded lysines called the "dilysine trigger." After pH is lowered to about 5.4, this [emphasize] insoluble ion dissociates from a complex and is converted into a soluble counterpart by STEAP3. It has nothing to do with cyanide poisoning, but methylene blue reacts with this ion to treat a condition that often manifests as blue skin. Since this ion is present in (*) [emphasize] aerobic environments, bacteria secrete enterobactin and other siderophores that scavenge this ion by binding to it with high affinity. Two species of this ion bind to transferrin with an association constant of 10 to the negative 22nd. The adjective "ferric" refers to, for 10 points, what metal cation, a more oxidized form of the ion found at the center of hemoglobin? ■END■
ANSWER: iron (III) ("iron three") [or Fe3+ ("F-E three plus”)]; or Fe (III); accept answers referring to Fe or iron with a +3 charge or oxidation state; accept ferric iron before "ferric"; prompt on iron or iron ion or Fe with "in what oxidation state?"; reject “ferrous iron”]
<Chen, Biology>
= Average correct buzz position