Electrochemical aptamer-based devices are of interest in an approach in which this quantity is adjusted in a "feedback-based" manner. Studies that estimate a range for this quantity may rely on the "continual reassessment approach." In a "3+3 design," this quantity is first "escalated" then "expanded" to determine a quantity called the R2PD. An adaptive stress response is often responsible for a biphasic response to this quantity, a phenomenon called (*) hormesis. Curves describing the relation between tissue response and this quantity typically follow the Hill equation. Phase 1 studies typically aim to establish the "maximum tolerated" value of this quantity. The toxicity of a xenobiotic can be expressed as the value of this quantity at which it is lethal to 50% of patients. For 10 points, name this quantity that describes how much of a drug is administered to a patient. ■END■
ANSWER: drug dose [or drug concentration; accept maximum tolerated dose; accept answers referring to the mass or volume of drug administered; accept median lethal dose or LD50; accept dosage; prompt on answers referring to the amount of ionization or radiation received; prompt on answers that refer to how much or the amount of a drug administered without specifying a specific quantity]
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