Note to moderator: Read answerline carefully. Since its 2005 FDA approval, a prodrug that competes with one of these compounds has been added to chemotherapy regimens to noticeably increase survival from T-cell acute lymphoblastic leukemia. NBMPR inhibits a bidirectional transporter of these compounds, a family of which, exemplified by SLC28, uses a sodium gradient to move these compounds [emphasize] against their concentration. The pancreatic cancer drug gemcitabine is imported by transceptors that act on these compounds, which in humans are classified as either (*) “concentrative” or “equilibrative.” The kinases TK1 and NME triply phosphorylate an antiviral drug resembling one of these compounds with a 3-prime azido group replacing a hydroxyl. A family of reverse transcriptase inhibitors, exemplified by AZT, disrupt DNA replication by acting as analogues of these compounds. For 10 points, name these phosphate-lacking metabolites consisting of a five-carbon sugar and a nitrogenous base. ■END■
ANSWER: nucleosides [accept nucleoside analog reverse transcriptase inhibitors or nucleoside transporter; prompt on nucleobases; prompt on purines or pyrimidines; prompt on hENTs or hCNTs; reject “nucleotides” or “nucleic acids”]
<RH, Biology>
= Average correct buzz position