nucleosides - 2024 Chicago Open

Question

Note to moderator: Read answerline carefully. Since its 2005 FDA approval, a prodrug that competes with one of these compounds has been added to chemotherapy regimens to noticeably increase survival from T-cell acute lymphoblastic leukemia. NBMPR inhibits a bidirectional transporter of these compounds, a family of which, exemplified by SLC28, uses a sodium gradient to move these compounds [emphasize] against their concentration. The pancreatic cancer drug gemcitabine is imported by transceptors that act on these (-5[1])compounds, which in humans are classified as either (*) “concentrative” or “equilibrative.” The kinases TK1 and NME triply phosphorylate an antiviral drug resembling one of these (-5[1])compounds with a 3-prime azido group replacing a (10[1])hydroxyl. A family of reverse (-5[1])transcriptase inhibitors, exemplified by (10[1]-5[2])AZT, disrupt DNA (-5[1])replication by acting as analogues of these compounds. For 10 points, name these phosphate-lacking metabolites consisting of a five-carbon sugar and a (10[1])nitrogenous base. (10[7]0[4])■END■

ANSWER: nucleosides [accept nucleoside analog reverse transcriptase inhibitors or nucleoside transporter; prompt on nucleobases; prompt on purines or pyrimidines; prompt on hENTs or hCNTs; reject “nucleotides” or “nucleic acids”]

<RH, Biology>

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Summary


2024 Chicago Open	07/28/2024	Y	14	71%	0%	43%	136.50

Buzzes

Player	Team	Opponent	Buzz Position	Value
Billy Busse	BHSU B	A Nervy Liberal Nanny Hence	74	-5
Andrew Wang	Punished "Venom" BHSU	it's the great pumpkinification objection, charlie brown	99	-5
Eric Mukherjee	LMM's LLM MLM	The Dyatlov Passement incident	107	10
June Yin	Les Missourables	var merchants	112	-5
Walter Zhao	Read slowly: A A A A A A A A A A A A A A A Read quickly: A	Are You There, Chat? It's Me, Margaret	116	10
Daniel Ma	There are buzzable clues everywhere for those with eyes to see	Lisan al-Quib	116	-5
Kevin Wang	genAI this, genAI that, have you found your 真爱 yet	First Cause, First Cause, make me young!	116	-5
Arya Karthik	Charlotte's Moderately Successful Team	NJTRANSit (and bobby, i guess)	119	-5
Gautam Kandlikar	when you look this good, you don’t have to know anything	Mindgoblin of Little Hobbes	141	10
Annabelle Yang	A Nervy Liberal Nanny Hence	BHSU B	143	10
Sky Hong	NJTRANSit (and bobby, i guess)	Charlotte's Moderately Successful Team	143	0
Richard Niu	AMOGH QUIZ HACK? 英雄联盟 400 PPG 24 TUH	Galvanized Square Steen and Eco-Friendly Wood Vermeer	143	10
Jeremy Tsai	I’ll take a quiet 10 / A handshake of CO (Chicago Open)	The Empire Bikes Back	143	10
Gareth Thorlakson	The Empire Bikes Back	I’ll take a quiet 10 / A handshake of CO (Chicago Open)	143	0
Rahul Keyal	Lying on a Mattress at Lou’s Apartment in Pilsen, Chicago	The Oldest Men in the World	143	0
Jason Hong	The Jeam Team	NJTRANSit (and anwen, I guess)	143	10
Natan Holtzman	Lisan al-Quib	There are buzzable clues everywhere for those with eyes to see	143	10
Nikhil Desai	First Cause, First Cause, make me young!	genAI this, genAI that, have you found your 真爱 yet	143	10
Alex Akridge	We Need New Names	sticking out your guyot for the ridge push; you're so seafloor spread, you're so fracture zone	143	10
Rohan Kher	var merchants	Les Missourables	143	0