Question
This enzyme contains a “peripheral anionic site” where aromatic residues bind to the quaternary ammonium cation of its substrate. For 10 points each:
[10h] Name this enzyme with a serine-histidine-glutamate catalytic triad. It is difficult to reactivate this enzyme with oximes (“OX-eems”) after its active site undergoes dealkylation and becomes “aged.”
ANSWER: acetylcholinesterase [or AChE or AChase; accept acetylcholine acetylhydrolase; reject “acetylcholine” or “ACh”]
[10e] Two answers required. Many nerve agents that inhibit acetylcholinesterase contain a central double bond between these two elements. A 1.5-angstrom double bond between these two non-carbon elements is formed in the Wittig reaction.
ANSWER: oxygen AND phosphorus [or O in place of “oxygen”; or P in place of “phosphorus”; accept in either order; accept organophosphates or organophosphorus compounds]
[10m] This is the most notable member of a family of nerve agents where the central phosphorus is bonded to sulfur instead of a halide. This nerve agent was used to assassinate Kim Jong-nam in 2017.
ANSWER: VX [or venomous agent X; prompt on V-series]
<KP, Chemistry>
Summary
| 2024 Chicago Open | 07/28/2024 | Y | 14 | 7.14 | 43% | 21% | 7% |
Data
| A Nervy Liberal Nanny Hence | sticking out your guyot for the ridge push; you're so seafloor spread, you're so fracture zone | 0 | 10 | 0 | 10 |
| Are You There, Chat? It's Me, Margaret | Lying on a Mattress at Lou’s Apartment in Pilsen, Chicago | 0 | 10 | 0 | 10 |
| First Cause, First Cause, make me young! | Berkeley Mafia and the Chicago Boy | 0 | 0 | 0 | 0 |
| Charlotte's Moderately Successful Team | Read slowly: A A A A A A A A A A A A A A A Read quickly: A | 0 | 0 | 0 | 0 |
| LMM's LLM MLM | I’ll take a quiet 10 / A handshake of CO (Chicago Open) | 0 | 10 | 10 | 20 |
| AMOGH QUIZ HACK? 英雄联盟 400 PPG 24 TUH | Lisan al-Quib | 0 | 0 | 0 | 0 |
| Mindgoblin of Little Hobbes | SAYYID QUTB, DRIVING THE LONGEST CAR YOU’VE EVER SEEN THROUGH TAHRIR SQUARE | 0 | 0 | 0 | 0 |
| BHSU B | The Dyatlov Passement incident | 10 | 10 | 0 | 20 |
| The Empire Bikes Back | Punished "Venom" BHSU | 0 | 0 | 0 | 0 |
| The Jeam Team | Les Missourables | 0 | 10 | 0 | 10 |
| Galvanized Square Steen and Eco-Friendly Wood Vermeer | The Oldest Men in the World | 0 | 10 | 0 | 10 |
| NJTRANSit (and bobby, i guess) | There are buzzable clues everywhere for those with eyes to see | 0 | 0 | 10 | 10 |
| it's the great pumpkinification objection, charlie brown | We Need New Names | 0 | 0 | 10 | 10 |
| when you look this good, you don’t have to know anything | NJTRANSit (and anwen, I guess) | 0 | 0 | 0 | 0 |