Question
The Immunological Genome Project, or ImmGen, is a collaborative effort to characterize gene expression underlying the immune system of this model organism. For 10 points each:
[10e] Name this mammalian model organism supplied by the Jackson Laboratory, whose inbred strains include C57BL/6. Capecchi, Evans, and Smithies won the 2007 Nobel Prize for their work with “knockouts” of this organism.
ANSWER: laboratory mouse [or laboratory mice; or Mus musculus; or M. musculus]
[10h] When analyzing gene expression data, researchers will commonly perform this powerful analytic method that takes groups of genes with shared functions and ranks them by correlation between expression and class distinction. MSigDB houses data for this technique.
ANSWER: GSEA [or gene set enrichment analysis, functional enrichment analysis, or pathway enrichment analysis]
[10m] Cancer genetics experiments commonly use a 50-pathway gene set produced by MSigDB with this one-word name. In 2011, “genomic instability” was added to a list of six characteristics of cancer cells titled for this word.
ANSWER: hallmarks [accept “Hallmarks of Cancer”]
<RH, Biology>
Summary
| 2024 Chicago Open | 07/28/2024 | Y | 15 | 13.33 | 100% | 33% | 0% |