Question
ROSE elements and the FourU thermometer are temperature-responsive sensors found within these regions in mRNAs that encode multiple heat-shock proteins. For 10 points each:
[10m] Name this noncoding region that in eukaryotes ends with the first six nucleotides of the Kozak sequence. This is the predominant region captured by CAGE-seq (“cage-seek”).
ANSWER: 5-prime untranslated region [or 5-prime UTR or leader sequence or transcript leader or leader RNA; prompt on Shine–Dalgarno sequence by asking “what broader region of the mRNA is that in?”; prompt on 5-prime-cap or the 5-prime end of mRNA; prompt on untranslated region or UTR]
[10e] 5-prime UTRs frequently exhibit secondary structures like hairpin loops due to their relative richness for these two nucleotides. Base pairs between these two nucleotides form three hydrogen bonds.
ANSWER: guanine AND cytosine [accept G in place of “guanine”; accept C in place of “cytosine”]
[10h] During translation initiation in eukaryotes, scanning begins with this complex traversing the 5-prime UTR until it hits an initiation sequence. This complex is pre-formed from the small ribosomal subunit, multiple eIFs, and the ternary Met-tRNA complex before being brought to the 5-prime cap.
ANSWER: 43s preinitiation complex [or 43S PIC]
<AA/RH, Biology>
Summary
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