Question

This pathway is initiated by its namesake protein binding to the receptors, LRP and Frizzled. For 10 points each:
[10h] Name this signaling pathway whose canonical type allows beta-catenin to dissociate from the destruction complex. Knockout of an analog of this pathway’s namesake protein in Drosophila leads to a “wingless” phenotype.
ANSWER: Wnt (went) pathway
[10e] After being liberated from the destruction box, beta-catenin can localize into this organelle and promote Wnt target gene expression. This organelle contains most of a cell’s genetic material.
ANSWER: cell nucleus
[10m] In one noncanonical Wnt pathway, Dishevelled mediates the binding of profilin to this protein to speed up polymerization at the plus end. During treadmilling, this protein leaves the polymer’s minus end as its G-form.
ANSWER: actin [accept G-actin; accept F-actin]
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Data

VassarMichigan C100010
Case WesternVassar010010
StanfordIowa State0101020
IowaMichigan A010010
Penn State BMichigan C010010
North CarolinaWUSTL10101030
Penn State AOhio0101020
Ohio StateMichigan B010010