Question
This pathway is initiated by its namesake protein binding to the receptors, LRP and Frizzled. For 10 points each:
[10h] Name this signaling pathway whose canonical type allows beta-catenin to dissociate from the destruction complex. Knockout of an analog of this pathway’s namesake protein in Drosophila leads to a “wingless” phenotype.
ANSWER: Wnt (went) pathway
[10e] After being liberated from the destruction box, beta-catenin can localize into this organelle and promote Wnt target gene expression. This organelle contains most of a cell’s genetic material.
ANSWER: cell nucleus
[10m] In one noncanonical Wnt pathway, Dishevelled mediates the binding of profilin to this protein to speed up polymerization at the plus end. During treadmilling, this protein leaves the polymer’s minus end as its G-form.
ANSWER: actin [accept G-actin; accept F-actin]
<Science - Biology>
Summary
| 2024 Booster Shot (Columbia) | 02/23/2024 | Y | 6 | 11.67 | 83% | 17% | 17% |
| 2024 Booster Shot (Great Lakes) | 03/09/2024 | Y | 7 | 15.71 | 100% | 43% | 14% |
| 2024 Booster Shot (Great Lakes) | 03/09/2024 | Y | 1 | 10.00 | 0% | 0% | 100% |
| 2024 Booster Shot (Vanderbilt) | 03/02/2024 | Y | 3 | 10.00 | 100% | 0% | 0% |
| 2024 Booster Shot (WUSTL) | 03/09/2024 | Y | 3 | 20.00 | 100% | 67% | 33% |
| 2024 Booster Shot (Waterloo) | 02/23/2024 | Y | 4 | 22.50 | 100% | 50% | 75% |
Data
| Vassar | Michigan C | 10 | 0 | 0 | 10 |
| Case Western | Vassar | 0 | 10 | 0 | 10 |
| Stanford | Iowa State | 0 | 10 | 10 | 20 |
| Iowa | Michigan A | 0 | 10 | 0 | 10 |
| Penn State B | Michigan C | 0 | 10 | 0 | 10 |
| North Carolina | WUSTL | 10 | 10 | 10 | 30 |
| Penn State A | Ohio | 0 | 10 | 10 | 20 |
| Ohio State | Michigan B | 0 | 10 | 0 | 10 |