Question
Charles David Allis discovered that this modification is performed by p55 in Tetrahymena. The reverse of this modification is suppressed by Trichostatin A and sodium butyrate in vivo. The yeast subunit Esa1 is part of the NuA4 enzyme, which performs this modification; that subunit is homologous to the human Tip60, which is part of the MYST family of enzymes that perform this modification. The SAGA complex includes a GCN5 subunit that performs this modification. An all-alpha fold is adopted by a (*) 110-amino acid domain that recognizes this modification called bromodomains. HDACs reverse this modification that occurs at lysine residues on H3 and H4. Unlike methylation, this modification increases transcriptional activity in chromatin. For 10 points, HATs perform what post-translational modification of histones that add a COCH3 group? ■END■
Buzzes
| Player | Team | Opponent | Buzz Position | Value |
|---|---|---|---|---|
| Caleb Ott | Tensei Shitara Flashcard Data Ken | Moderator Can't Neg me While in Alpha | 89 | -5 |
| Raymond Chen | She Dicer On My Argonaute Till I RNA Interfere | as rational as the square root of two power bottoms | 89 | 10 |
| Kane Nguyen | I'd prefer to have the team name be Christensen et al. than anything that Erik cooks up | The Only Existing Manuscript from A Clockwork Orange | 89 | -5 |
| Benjamin Chapman | Simpson Agonistes: The Crisis of Donut | Ryan Wesley Routh's 10 000 NATO-trained Afghan Quizbowlers | 104 | 10 |
| Sheena Li | Communism is Soviet power plus the yassification of the whole country | You cannot go to Aarhus to see his peat-brown head / With eyes like ripening fruit | 106 | 10 |
| Adrian Wong | The Only Existing Manuscript from A Clockwork Orange | I'd prefer to have the team name be Christensen et al. than anything that Erik cooks up | 127 | 10 |