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Using sea stars and sea urchins, Brown’s PRIMO lab showed that interactions between Gustavus and Vasa are conserved in inherited and induced modes of specifying this cell lineage. For 10 points each:
[10m] Name these cells that, in Drosophila, migrate from a “plasm” established by Oskar. Granulosa cells and Sertoli cells nourish distinct populations of these stem cells as they differentiate into mature haploid cell types.
ANSWER: germ cells [or gametocytes; accept germline; accept germplasm; accept primordial germ cells; prompt on PGCs by asking “what does that stand for?”; reject “gametes” or “sperm” or “oocytes” or “eggs”]
[10e] Gustavus represses Vasa expression outside the germline by tagging it with this degradation signal, a protein named for its widespread presence in eukaryotic cells.
ANSWER: ubiquitin [or Ub; accept ubiquitination or ubiquitylation; accept ubiquitin ligase]
[10h] Unlike Vasa, this other germline factor is not post-translationally degraded when introduced to the soma. Bicoid and this maternally deposited mRNA specify the Drosophila embryo’s anterior-posterior axis.
ANSWER: Nanos [or Nos]
<JE, Biology>

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