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Notch’s opa domains include large tracts of this amino acid, whose instability can cause bristling if they are overextended. For 10 points each:
[10m] Name this amino acid, which comprises extensive tracts that aggregate and cause neurodegeneration in diseases such as Huntington’s. Most ammonia is transported to the liver in the form of this amino acid.
ANSWER: glutamine [or Q or Gln; accept polyglutamine or polyQ]
[10h] This organism is used to study polyglutamine diseases because its SRCP1 protein solubilizes polyglutamine tracts. When starved, this slime mold secretes cyclic AMP (“A-M-P”) to aggregate its cells into a pseudoplasmodium.
ANSWER: Dictyostelium [or Dictyostelium discoideum or D. discoideum; accept Dicty]
[10e] Expanding the Huntingtin polyglutamine tract can abnormally orient cristae and reduce levels of Complex IV in the inner membrane of these ATP-generating organelles.
ANSWER: mitochondria [or mitochondrion]
<JE, Biology>

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