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“Co-” examples of these materials for drugs can be engineered with the synthon approach. For 10 points each:
[10e] Name these materials that most drugs are formulated as. In these highly-ordered materials, atoms occupy a spatially-periodic lattice.
ANSWER: crystals [accept cocrystals; accept crystalline materials]
[10m] The original crystal form for a drug can no longer be synthesized when it has a “disappearing” example of these states, a hitch that tanked the development of ritonavir and paroxetine. This term refers to any of the multiple crystal structures that a compound can crystallize into.
ANSWER: polymorphs [accept disappearing polymorphs]
[10h] The most polymorphic compound in the Cambridge Structural Database, R·O·Y, is an intermediate in the synthesis of olanzapine, a drug in this class. Paul Janssen's group developed a pioneering drug in this class, haloperidol, by iterating on pethidine.
ANSWER: anti-psychotics [or neuroleptic drugs; or major tranquilizers; prompt on psychotropic or psychoactive drugs; prompt on anti-schizophrenics or anti-bipolar drugs; prompt on tranquilizers; prompt on mood stabilizers; accept typical or atypical or first-generation or second-generation anti-psychotics]
<VD, Chemistry>

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TrumanMissouri100010
WashUSquidward Community College10101030