Question
These proteins’ “4A” subtype includes an isoform that directly binds microtubules during axonal growth, independently of its usual function in RNA dynamics. For 10 points each:
[10h] Name this class of RNA-binding proteins whose 4A, 4E, and 4G subtypes form a “4F” heterotrimer that binds the 5’ (“five-prime”) cap during translation.
ANSWER: eukaryotic initiation factors [or EIFs; reject “EFs”]
[10e] EIF4A3 (“E-I-F-four-A-three”) canonically forms the core of a “junction complex” named for these coding sequences within mRNA, which are left behind during splicing after introns are removed.
ANSWER: exons [accept exon junction complex]
[10m] Exon junction complexes that are not displaced during translation trigger a form of mRNA decay mediated by these mutations. These mutations create premature “opal,” “amber,” or “ochre” codons.
ANSWER: nonsense mutations [accept nonsense-mediated decay; accept stop-gain mutations]
<JE, Biology>
Summary
| 2024 ARCADIA at BU | 2024-12-06 | Y | 4 | 7.50 | 50% | 25% | 0% |
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