Question
These proteins’ “4A” subtype includes an isoform that directly binds microtubules during axonal growth, independently of its usual function in RNA dynamics. For 10 points each:
[10h] Name this class of RNA-binding proteins whose 4A, 4E, and 4G subtypes form a “4F” heterotrimer that binds the 5’ (“five-prime”) cap during translation.
ANSWER: eukaryotic initiation factors [or EIFs; reject “EFs”]
[10e] EIF4A3 (“E-I-F-four-A-three”) canonically forms the core of a “junction complex” named for these coding sequences within mRNA, which are left behind during splicing after introns are removed.
ANSWER: exons [accept exon junction complex]
[10m] Exon junction complexes that are not displaced during translation trigger a form of mRNA decay mediated by these mutations. These mutations create premature “opal,” “amber,” or “ochre” codons.
ANSWER: nonsense mutations [accept nonsense-mediated decay; accept stop-gain mutations]
<JE, Biology>
Summary
| 2024 ARCADIA at BU | 2024-12-06 | Y | 4 | 7.50 | 50% | 25% | 0% |
| 2024 ARCADIA at Duke | 2024-12-06 | Y | 2 | 15.00 | 100% | 50% | 0% |
| 2024 ARCADIA Online | 2025-05-17 | Y | 5 | 14.00 | 60% | 80% | 0% |
| 2024 ARCADIA at Penn State | 2024-12-06 | Y | 1 | 10.00 | 100% | 0% | 0% |
| 2024 ARCADIA at Florida Tech | 2024-12-06 | Y | 3 | 10.00 | 67% | 33% | 0% |
| 2024 ARCADIA at UC Berkeley | 2024-12-06 | Y | 2 | 20.00 | 100% | 50% | 50% |
| 2024 ARCADIA at Waterloo | 2024-11-09 | Y | 4 | 17.50 | 100% | 75% | 0% |
| 2024 ARCADIA at GT | 2024-12-06 | Y | 1 | 20.00 | 100% | 100% | 0% |
| 2024 ARCADIA at Illinois | 2024-11-09 | Y | 4 | 15.00 | 75% | 75% | 0% |
| 2024 ARCADIA at Warwick | 2024-12-06 | Y | 4 | 5.00 | 50% | 0% | 0% |
| 2024 ARCADIA at Claremont | 2024-11-02 | Y | 3 | 16.67 | 100% | 67% | 0% |
Data
| Boston College A | Amherst | 0 | 0 | 0 | 0 |
| Brandeis B | Harvard | 0 | 0 | 0 | 0 |
| MIT | Tufts A | 0 | 10 | 10 | 20 |
| Yale | Tufts B | 0 | 10 | 0 | 10 |
| North Carolina A | North Carolina B | 0 | 10 | 10 | 20 |
| Virginia Tech B | Virginia Tech A | 0 | 10 | 0 | 10 |
| The cult of SGA | ASU->Stanford->ASU pipeline | 0 | 0 | 0 | 0 |
| Paddington in Peru (2024) | Toyota Tundra Turbos — Twisting Truths - Tackling Trivia - Taming Titans | 0 | 0 | 10 | 10 |
| she limp on my waltz till i feel pathetique | Social credit go vroom | 0 | 10 | 10 | 20 |
| bingy academy | Madmen and Specialists | 0 | 10 | 10 | 20 |
| In the Mood for Buzz | Old and Young | 0 | 10 | 10 | 20 |
| Pitt | Maryland | 0 | 10 | 0 | 10 |
| Florida Tech | UF A | 0 | 10 | 10 | 20 |
| UCF B | UF B | 0 | 0 | 0 | 0 |
| UCF A | Valencia | 0 | 10 | 0 | 10 |
| Berkeley Past | Berkeley A | 10 | 10 | 10 | 30 |
| Stanford | Berkeley B | 0 | 10 | 0 | 10 |
| McGill A | McMaster ApocolocyntosisBidii | 0 | 10 | 0 | 10 |
| Toronto A | Toronto Disband the Club 2k24 | 0 | 10 | 10 | 20 |
| Waterloo Aspidistra | Ottawa Absolomabsolomabsolom | 0 | 10 | 10 | 20 |
| Toronto B | Waterloo Basic | 0 | 10 | 10 | 20 |
| Georgia Tech B | Lambert | 0 | 10 | 10 | 20 |
| Chicago A | SIUE | 0 | 10 | 10 | 20 |
| Illinois Orange | Chicago B | 0 | 0 | 0 | 0 |
| Illinois Blue | Purdue A | 0 | 10 | 10 | 20 |
| Notre Dame | Purdue B | 0 | 10 | 10 | 20 |
| Bristol | Cambridge B | 0 | 0 | 0 | 0 |
| Imperial A | Warwick C | 0 | 10 | 0 | 10 |
| Warwick B | Imperial B | 0 | 10 | 0 | 10 |
| LSE A | LSE B | 0 | 0 | 0 | 0 |
| ALCU | Anderson et al. | 0 | 10 | 10 | 20 |
| Claremont | Jason et al. | 0 | 10 | 10 | 20 |
| U[C]SD | SGV Ventures | 0 | 10 | 0 | 10 |