eukaryotic initiation factors - 2024 ARCADIA

Question

These proteins’ “4A” subtype includes an isoform that directly binds microtubules during axonal growth, independently of its usual function in RNA dynamics. For 10 points each:

[10h] Name this class of RNA-binding proteins whose 4A, 4E, and 4G subtypes form a “4F” heterotrimer that binds the 5’ (“five-prime”) cap during translation.

ANSWER: eukaryotic initiation factors [or EIFs; reject “EFs”]

[10e] EIF4A3 (“E-I-F-four-A-three”) canonically forms the core of a “junction complex” named for these coding sequences within mRNA, which are left behind during splicing after introns are removed.

ANSWER: exons [accept exon junction complex]

[10m] Exon junction complexes that are not displaced during translation trigger a form of mRNA decay mediated by these mutations. These mutations create premature “opal,” “amber,” or “ochre” codons.

ANSWER: nonsense mutations [accept nonsense-mediated decay; accept stop-gain mutations]

<JE, Biology>

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Summary


2024 ARCADIA at BU	2024-12-06	Y	4	7.50	50%	25%	0%
2024 ARCADIA at Duke	2024-12-06	Y	2	15.00	100%	50%	0%
2024 ARCADIA Online	2025-05-17	Y	5	14.00	60%	80%	0%
2024 ARCADIA at Penn State	2024-12-06	Y	1	10.00	100%	0%	0%
2024 ARCADIA at Florida Tech	2024-12-06	Y	3	10.00	67%	33%	0%
2024 ARCADIA at UC Berkeley	2024-12-06	Y	2	20.00	100%	50%	50%
2024 ARCADIA at Waterloo	2024-11-09	Y	4	17.50	100%	75%	0%
2024 ARCADIA at GT	2024-12-06	Y	1	20.00	100%	100%	0%
2024 ARCADIA at Illinois	2024-11-09	Y	4	15.00	75%	75%	0%
2024 ARCADIA at Warwick	2024-12-06	Y	4	5.00	50%	0%	0%
2024 ARCADIA at Claremont	2024-11-02	Y	3	16.67	100%	67%	0%

Data


Boston College A	Amherst	0	0	0	0
Virginia Tech B	Virginia Tech A	0	10	0	10
Illinois Orange	Chicago B	0	0	0	0
Notre Dame	Purdue B	0	10	10	20
Warwick B	Imperial B	0	10	0	10
LSE A	LSE B	0	0	0	0
ALCU	Anderson et al.	0	10	10	20
Claremont	Jason et al.	0	10	10	20
Brandeis B	Harvard	0	0	0	0
MIT	Tufts A	0	10	10	20
Yale	Tufts B	0	10	0	10
North Carolina A	North Carolina B	0	10	10	20
The cult of SGA	ASU->Stanford->ASU pipeline	0	0	0	0
In the Mood for Buzz	Old and Young	0	10	10	20
bingy academy	Madmen and Specialists	0	10	10	20
Florida Tech	UF A	0	10	10	20
UCF A	Valencia	0	10	0	10
Toronto A	Toronto Disband the Club 2k24	0	10	10	20
Waterloo Aspidistra	Ottawa Absolomabsolomabsolom	0	10	10	20
Chicago A	SIUE	0	10	10	20
Illinois Blue	Purdue A	0	10	10	20
Bristol	Cambridge B	0	0	0	0
Imperial A	Warwick C	0	10	0	10
U[C]SD	SGV Ventures	0	10	0	10
Paddington in Peru (2024)	Toyota Tundra Turbos — Twisting Truths - Tackling Trivia - Taming Titans	0	0	10	10
she limp on my waltz till i feel pathetique	Social credit go vroom	0	10	10	20
Pitt	Maryland	0	10	0	10
UCF B	UF B	0	0	0	0
Berkeley Past	Berkeley A	10	10	10	30
Stanford	Berkeley B	0	10	0	10
McGill A	McMaster ApocolocyntosisBidii	0	10	0	10
Toronto B	Waterloo Basic	0	10	10	20
Georgia Tech B	Lambert	0	10	10	20