Question

After cells take up one form of this molecule, it becomes accessible for antibody labeling after its target is hydrolyzed with HCl (“h-c-l”) and borax. That form of this molecule is often co-stained with Ki67 (“k-i-67”). This non-methylated molecule is the larger product of a reaction catalyzed by APOBECs, which underpins the first step of bisulfite sequencing. Ethynyl- and bromo·de·oxy derivatives of this molecule are used to detect cell proliferation. The letter (*) psi denotes a form of this molecule that may help strengthen binding to the 30S subunit in one structure’s stem-loops. (-5[1])This molecule is generated by de·aminating cytosine, and methylating this molecule’s (10[1])5’ (“five-prime”) carbon yields its more mutation-resistant (-5[1])analog that similarly forms two hydrogen bonds with adenine. (-5[1])For 10 points, what base replaces thymine in RNA? ■END■ (10[4]0[1])

ANSWER: uracil [or U; or uridine; accept bromodeoxyuridine or BrdU; accept ethynyl deoxyuridine or EdU; accept pseudouridine; prompt on thymine or thymidine until “APOBECs” is read by asking “thymine/thymidine is a derivative of what other molecule?”]
<JE, Biology>
= Average correct buzz position

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Buzzes

PlayerTeamOpponentBuzz PositionValue
Darren KellisMiltonJohns Creek89-5
Shaun IyerInnovation Academy AGeorgia Tech B10010
Adhrit YadavLambertGeorgia Tech D106-5
Rohan DalalGeorgia Tech AGeorgia Tech C115-5
Pranav JothiGeorgia Tech CGeorgia Tech A12510
Joanna XiaoGeorgia Tech DLambert12510
Edward KimJohns CreekMilton12510
Pratyusha SoniInnovation Academy BMississippi State12510
Towery McNeilMississippi StateInnovation Academy B1250

Summary