Question

Synthesis of this compound is rate-limited by an enzyme that the W317X (“w-three-seventeen-x”) mutation truncates in Tourette’s syndrome. This is the main substrate of a copper-dependent enzyme that also metabolizes putrescine and cadaverine. Patients with intolerance for this compound take diamine oxidase supplements to break down this compound (-5[1])and avoid scombroid poisoning. The first blockbuster drug, cimetidine, selectively inhibits parietal cells’ receptors for this compound to treat (*) stomach ulcers. This compound is made by decarboxylating an imidazole-containing amino acid. The OTC drugs loratadine and cetirizine block this compound’s activity after IgE causes its release from mast cells, preventing a runny (10[1])nose and itching. For 10 points, seasonal allergies are treated by drugs that target what inflammatory compound? ■END■ (10[1])

ANSWER: histamine [accept antihistamines]
<VD, Biology>
= Average correct buzz position

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Buzzes

PlayerTeamOpponentBuzz PositionValue
Kevin CronkVirginia Tech CSouth Carolina46-5
Emily KadolphVirginia Tech BVirginia Tech A9810
John McQueenSouth CarolinaVirginia Tech C11610
Benjamin McAvoy-BickfordNorth Carolina ANorth Carolina B13110