Question

This compound and its derivatives are both the source of, and the target for, electrons shuttled across the chromaffin granule membrane, because it is typically imported in its oxidized form. Oxidation of this compound is classically said to produce a 1,2,3-triketone (“1-2-3-try-KEE-tone”), although in vivo a bicyclic hemiketal (“hemi-KEE-tal”) is formed almost immediately. This compound’s (-5[1])degradation concludes with cleavage of its gamma-lactone ring. This compound can perform one single-electron transfer before undergoing disproportionation and being regenerated by glutathione (“gloo-tuh-THIGH-own”). This compound (10[1]-5[1])is capable of rescuing non-heme (-5[1])hydroxylases by reducing their iron(III) (“iron-three”) centers back to the active plus-2 state, (10[1])making it (10[1])essential for the function of lysyl (“LYE-sill”) and prolyl hydroxylase. (10[1])For 10 points, name this cofactor in the synthesis of collagen, (10[2]-5[1])a water-soluble (10[1])dietary (10[3])vitamin. (10[2])■END■ (10[4]0[8])

ANSWER: vitamin C [or L-ascorbic acid or ascorbate; accept dehydroascorbate or semidehydroascorbate or monodehydroascorbate; accept C after “vitamin” is read; prompt on AAH, DHA, MDHA, or SDHA by asking “what does that stand for?”]
<Chemistry>
= Average correct buzz position

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Summary

2024 ACF Nationals2024-04-21Y2176%0%19%112.69

Buzzes

PlayerTeamOpponentBuzz PositionValue
Yashwanth BajjiMichiganBerkeley A52-5
Annabelle YangWUSTL AHarvard77-5
Nikhil ChellamNorthwesternMaryland7710
Andrew WangIllinoisMcGill82-5
Amith PunyalaWUSTL BArizona State9410
Kushal AluruRutgersDuke9610
Matt SchiavonePurdueVanderbilt10510
Jason HongBrownColumbia A11610
Joseph ChambersVirginiaIowa State116-5
Vishal KanigicherlaPennYale B11610
Raymond ChenToronto ANorth Carolina A11810
Richard NiuCornell AColumbia B11910
Sinecio MoralesJohns HopkinsMinnesota B11910
Andrew MinagarYale ATexas11910
Tiffany ZhouFloridaBerkeley B12010
Allan LeeStanfordTruman State12010
Shahar SchwartzBerkeley AMichigan12110
Jason ZhangToronto BChicago D1210
Ezra SantosChicago DToronto B1210
Maude-Sophie LockmanOttawaClaremont Colleges1210
Kevin ParkClaremont CollegesOttawa1210
Yared TadesseCornell BChicago A12110
Jeffrey FungHarvardWUSTL A1210
Nicolas EdwardsMcGillIllinois1210
Conor ThompsonIowa StateVirginia12110
Alex AkridgeIndianaKentucky1210
Andrew EllisKentuckyIndiana1210
Robert CondronChicago BNYU12110