Question
Nonsteroidal drugs targeting this receptor, which include flutamide, are silent antagonists with lower affinity but fewer off-target effects. For 10 points each:
[10m] Name this nuclear receptor. Mutations in this protein can result in castration-resistant varieties of cancer.
ANSWER: androgen receptor [or AR; accept AR antagonists; accept nonsteroidal antiandrogens]
[10e] Antiandrogens are administered alongside these hormones in feminizing hormone replacement therapy. HRT aimed at menopausal women involves these hormones and progesterones.
ANSWER: estrogens [accept estradiol or estrone]
[10h] This drug is the first-choice antiandrogen for feminizing HRT everywhere but Japan and the US, where chlormadinone or spironolactone must be used instead. Direct comparisons indicate that this drug is markedly better at lowering testosterone than spiro but comes with a risk of liver damage.
ANSWER: cyproterone [accept cyproterone acetate or CPA; accept Androcur or Cyprostat]
<Biology>
Summary
| 2024 ACF Nationals | 2024-04-21 | Y | 20 | 11.00 | 100% | 5% | 5% |
Data
| Arizona State | Cornell B | 10 | 10 | 0 | 20 |
| Berkeley B | Virginia | 0 | 10 | 0 | 10 |
| Brown | Chicago C | 0 | 10 | 0 | 10 |
| Illinois | Columbia A | 0 | 10 | 0 | 10 |
| Waterloo | Columbia B | 0 | 10 | 0 | 10 |
| Cornell A | Chicago D | 0 | 10 | 0 | 10 |
| NYU | Duke | 0 | 10 | 0 | 10 |
| Georgia Tech | WUSTL B | 0 | 10 | 0 | 10 |
| Johns Hopkins | Harvard | 0 | 10 | 0 | 10 |
| Kentucky | Iowa State | 0 | 10 | 0 | 10 |
| Michigan | North Carolina B | 0 | 10 | 0 | 10 |
| Minnesota A | Claremont Colleges | 0 | 10 | 0 | 10 |
| Minnesota B | Rutgers | 0 | 10 | 0 | 10 |
| Indiana | North Carolina A | 0 | 10 | 0 | 10 |
| Ottawa | McGill | 0 | 10 | 10 | 20 |
| Stanford | Penn | 0 | 10 | 0 | 10 |
| Northwestern | Vanderbilt | 0 | 10 | 0 | 10 |
| WUSTL A | Chicago B | 0 | 10 | 0 | 10 |
| Chicago A | Yale A | 0 | 10 | 0 | 10 |
| Yale B | Purdue | 0 | 10 | 0 | 10 |