Question
A non-canonical route to this process involves the oligomerization of caspase-4 after it directly binds LPS, rather than the recruitment of caspase-1 by the CARD domain of ASC. For 10 points each:
[10h] Name this form of programmed cell death triggered by danger signals. This process is upregulated in individuals with familial Mediterranean fever and involves the cleavage of gasdermin D.
ANSWER: pyroptosis [prompt on inflammation]
[10m] Non-canonical splicing violates the typical assumption that this nucleobase lies on both ends of an intron. Extended sequences of this base can form planar quadruplexes due to Hoogsteen bonding.
ANSWER: guanine [accept guanosine; prompt on G or G-quadruplex]
[10e] The activation of ROCK (“rock”) by Wnt (“wint”) as part of the non-canonical cell polarity pathway triggers reorganization of actin filaments in this network, which provides structure to the cell.
ANSWER: cytoskeleton
<Biology>
Summary
| 2024 ACF Nationals | 2024-04-21 | Y | 3 | 16.67 | 100% | 67% | 0% |
Data
| Stanford | Cornell A | 0 | 10 | 10 | 20 |
| North Carolina A | Texas | 0 | 10 | 10 | 20 |
| Vanderbilt | North Carolina B | 0 | 0 | 10 | 10 |