A tumor type of this non-skin organ was classically described by the “rule of 10s.” Harvey, Kirsten, and a proto-oncogene named after a malignancy most often found in this organ comprise the human Ras genes. Greater amplification of the N-myc gene correlates with a worse prognosis for that pediatric tumor in this organ and often corresponds to increased levels of homovanillic acid. MIBG accumulates in cells in this organ that share an affinity for chromium salt staining with similarly named (*) serotonin-secreting “entero” cells in the GI tract. Pheochromocytomas originating from this organ's chromaffin cells can paroxysmally secrete high levels of catecholamines. This organ’s cortex secretes glucocorticoid hormones, including cortisol. For 10 points, name this paired organ whose medulla produces the majority of epinephrine. ■END■
ANSWER: adrenal glands [or suprarenal glands; or adrenal medulla; or adrenal cortex; The pediatric tumor is neuroblastoma.]
<Joelle Smart, Biology>
= Average correct buzz position